网站地图联系我们English中国科学院
首 页 中心介绍机构设置研究队伍重大项目科研装备科研成果研究生教育科学传播网上报销
 
  研究队伍
  院士  
  百人计划  
  杰青  
  优青  
  研究员  
  副研究员  
  助理研究员  
  研究组  
  您现在的位置:首页 > 研究队伍
  专家人才库

姓名 刘思金 性别:
职称 研究员 学历 博士
电话 010-62849050 传真: 0086-10-62849050
Email: sjliu@rcees.ac.cn 邮编: 100085
地址 北京市海淀区双清路18号
简历:

刘思金,男,研究员,博士生导师,中科院百人计划入选者,国家973项目首席科学家,国家杰出青年基金获得者。2004年毕业于中科院遗传发育所,获博士学位。2004年至2008年,先后在麻省理工学院(MIT)和哈佛医学院儿童医院完成博士后的学习。2008年至2009年,在塔夫斯大学医学院任讲师。2009年8月入选百人计划进入生态环境研究中心工作,2014年终期考评被评选为优秀。在Journal of Clinical Investigation, Cancer Research, ACS Nano, Oncogene, Biomaterials等期刊上发表论文100余篇。作为POPs研究集体的主要完成者,获中科院2013年度杰出科技成就奖等;获2015年度中科院青年科学家奖,2018年入选国家第三批“万人计划” 科技领军人才。

研究方向:

环境污染物与人类健康效应

招生方向:
环境医学与环境毒理学,欢迎生物,医学,材料等专业学生报考。
专家类别:
百人计划、研究员
职务:
环境化学与生态毒理学国家重点实验室副主任
社会任职:

担任国家“环境与健康专家咨询委员会”委员、中央国家机关青联委员和中科院青联委员等社会职务。

承担科研项目情况:

(1) 国家自然科学基金重点项目:高环境暴露风险金属纳米材料的胚胎发育毒性机制研究,项目批准号:21637004,2017.01-2021.12。
(2) 国家基金委杰出青年科学基金:环境污染物的毒理与健康效应,项目批准号: 21425731,2015.1-2019.12。
(3)国家科技部973项目:典型人工纳米材料的水环境过程、生物效应及其调控研究,项目批准号:2014CB932000,2014.1-2018.12。

获奖及荣誉:

中科院2013年度杰出科技成就奖;
中科院2015年度青年科学家奖;
中国科协、人社部、科技部2015年中国青年科技奖;
科技部2017年国家青年科技领军人才;
中组部2018年国家第三批“万人计划”。

代表论著:

1.Zhang, J., Wang, S., Gao, M., Li, R., Liu, S.* (2018) Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses. ACS Sustainable Chemistry & Engineering. 6(8):10374-10384.
2.Wu, Y., Wang, F., Wang, S., Ma, J., Xu, M., Gao, M., Liu, R, Chen, W.,* Liu, S.* (2018) Reduction of Graphene Oxide Alters Its Cyto-Compatibility towards Primary and Immortalized Macrophages. Nanoscale. 10:14637-14650.
3.Bai, X., Xu, M., Liu, S.,* Hu, G.* (2018) Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant. ACS Applied Materials & Interfaces. 10(24):20368-20376.
4.Ma, J., Guo, A., Wang, S., Man, S., Zhang, Y., Liu, S., Liu, Y.* (2018) From the Lung to the Knee Joint: Toxicity Evaluation of Carbon Black Nanoparticles on Macrophages and Chondrocytes. Journal of Hazardous Materials. 353:329-339.
5.Qi, Y., Liu, Y., Xia, T., Xu, A., Liu, S.,* Chen, W.* (2018) Biotransformation of Graphene Oxide in Lung Fluids Significantly Alters Its Inherent Properties and Bioactivities towards Immune Cells. NPG Asia Materials. 10:385-396.
6.Gao, M., Li, C., Xu, M., Liu, Y., Cong, M., Liu, S.* (2018) LncRNA MT1DP Aggravates Cadmium-induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with MiR-365. Advanced Science. 5:1800087.
7.Zhu, J., Xu, M., Wang, F., Gao, M., Zhang, Z., Xu, Y., Chen, W.,* Liu, S.* (2018) Low-dose Exposure of Graphene Oxide Significantly Increase Metal Toxicity to Macrophages by Altering Their Cellular Priming State. Nano Research. 11:4111-4122.
8.Yang, Y., Wu, Y., Ren, Q., Zhang, L., Liu, S.,* Zuo, Y*. (2018) Biophysical Assessment of Pulmonary Surfactant Predicts the Lung Toxicity of Nanomaterials. Small Methods. 2(4):1700367.
9.Gao, M., Chen, M., Li, C., Xu, M., Liu, Y., Cong, M., Snag, N., Liu, S.* (2018) Long Non-coding RNA MT1DP Shunts the Cellular Defense to Cytotoxicity through Crosstalk with MT1H and RhoC in Cadmium Stress. Cell Discovery. 4(1):5.
10.Wu, Y., Guo, Y., Song, H., Liu, W., Yang, Y., Liu, Y., Sang, N., Zuo, Y., Liu, S.* (2018) Oxygen Content Determines the Bio-reactivity and Toxicity Profiles of Carbon Black Particles. Ecotoxicology and Environmental Safety. 150:207-214.
11.Gao, J., Li, R., Wang, F., Liu, X., Zhang, J., Hu, L., Shi, J., He, B., Zhou, Q., Song, M., Zhang, B., Qu, G.,* Liu, S., Jiang, G. (2017) Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage. Environmental Science & Technology. 51(23):13938-13948.
12.Zhu, J., Xu, M.,* Gao, M., Zhang, Z., Xu, Y., Xia, T., Liu, S.* (2017) Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents. ACS Nano. 11(3):2637-2651.
13.Liu, J., Wang, L., Du, Y.,* Liu, S*. (2017) An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them Against Oxidative Stress. Advanced Science. 4(10):1700089.
14.Gao, M., Zhao, B., Chen, M., Liu, Y., Xu, M., Wang, Z., Liu, S.,* Zhang, C.,* (2017) Nrf-2-driven Long Noncoding RNA ODRUL Contributes to Modulating Silver Nanoparticle-Induced Effects on Erythroid Cells. Biomaterials. 130:14-27.
15.Wang, Z., Liu, H.,* Liu, S.,* (2017) Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer. Advanced Science. 4(2):1600248.
16.Ma, J., Li, R., Liu, Y., Qu, G., Liu, J., Guo, W., Song, H., Li, X., Liu, Y., Xia, T., Yan, B., Liu, S.* (2017) Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal-of-Entry. Small. 13(15):1603830.
17.Chen, Y., Wu, Y., Sun, B., Liu, S.,* Liu, H.* (2017) Two-Dimensional Nanomaterials for Cancer Nanotheranostics. Small. 13(10):1603446.
18.Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.,* Xu, Y., Liu, S.* (2017) Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment. Advanced Materials. 29(6):1604580.
19.Qu, G., Liu, A., Hu, L., Liu, S.,* Shi, J.* Jiang, G. (2016) Recent Advances in the Analysis of TBBPA/TBBPS, TBBPA/TBBPS Derivatives and Their Transformation Products. Trac Trends in Analytical Chemistry. 83:14-24.
20.Xia, T.,* Zhu, Y., Mu, L., Zhang, Z., Liu, S.* (2016) Pulmonary Diseases Induced by Ambient Ultrafine and Engineered Nanoparticles in Twenty-First Century. National Science Review. 3(4):416-429.
21.Ma, J., Li, R., Qu, G., Liu, H., Yan, B., Xia, T., Liu, Y., Liu, S.* (2016) Carbon Nanotubes Stimulate Synovial Inflammation by Inducing Systemic Pro-Inflammatory Cytokines. Nanoscale. 8(42):18070-18086.
22.Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.* Tian, J., Zhang, T.,* Liu, H.* (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Advanced Materials. 28(38):8379-8387.
23.Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.,* Zhang, Z.,* Chen, W., Liu, S.* (2016) Improved in Vitro and in Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10(3):3267-3281.
24.Gao, M., Liu, Y., Chen, Y., Yin, C., Chen, J., Liu, S.* (2016) miR-214 Protects Erythroid Cells Against Oxidative Stress by Targeting ATF4 and EZH2. Free Radical Biology & Medicine. 92:39-49.
25.Ma, J.,Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, R., Zuo, Y., Xia, T.,* Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9(10):10498-10515.
26.Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.,* Liu, S.* (2015) Silver Nanoparticle-Induced Hemoglobin Decrease Involves Alteration of Histone 3 Methylation Status. Biomaterials. 70:12-22.
27.Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid Zinc Finger 1 (MZF-1) Suppresses Prostate Tumor Growth through Enforcing Ferroportin-Conducted Iron Egress. Oncogene. 34(29):3839-3847.
28.Wang, Z., Xia, T.,* Liu, S.* (2015) Mechanisms of Nanosilver-Induced Toxicological Effects: More Attention Should be Oaid to Its Sublethal Effects. Nanoscale. 7(17):7470-7481.
29.Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y.,* Liu, S.* (2014) Nanosilver Incurs an Adaptive Shunt of Energy Metabolism Mode to Glycolysis in Tumor and Nontumor Cells. ACS Nano. 8(6):5813-5825.
30.Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a Crucial Role in Gegulating Prostate Tumor Growth through Interaction with c-Myc. Oncogene. 33(49):5582-5591.
31.Qu, G., Liu, S.,* Zhang, S., Wang, L., Wang, X., Sun, B., Yin, N., Gao, X., Xia, T., Chen, J., Jiang, G. (2013) Graphene Oxide Induces Toll-Like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7(7):5732-5745.
32.Wang, Z., Liu, S.,* Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013) Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7(5):4171-4186.
33.Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, Jiang, G. (2012) Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4(7):2239-2244.
34.Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., Chen, J.J.* (2012) Heme-Regulated eIF2alpha Kinase Activated Atf4 Signaling Pathway in Oxidative Stress and Erythropoiesis. Blood. 119(22):5276-5284.
35.Liu, S., Goldstein, R.H., Scepansky, E.M., Rosenblatt, M.* (2009) Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Research. 69:(22)8742-8751.
36.Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., Chen, J.J.* (2007) The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. Journal of Clinical Investigation. 117(11):3296-3305.


  建议您使用IE6.0以上版本浏览器 屏幕设置为1024 * 768 为最佳效果
版权所有:中国科学院生态环境研究中心 Copyright.2009
地址:北京市海淀区双清路18号 100085 京ICP备05002858号 文保网安备案号:110402500010号