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姓名 赵斌 性别:
职称 研究员 学历 博士
电话 010-62842867 传真:
Email: binzhao@rcees.ac.cn 邮编: 100085
地址 北京市海淀区双清路18号
简历:

教育经历

1998/9–2002/7,香港科技大学,生物学,博士

1994/9–1998/7,中国海洋大学,海洋生物学,学士

工作经历

2009/7-至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,研究员,博士生导师

2003/1-2009/7,美国加州大学(University of California, Davis),环境毒理学系,博士后

研究方向:
持久性有机污染物的毒理效应及机制更多信息,请见:http://et.rcees.ac.cn/rcdw/yjz/z1_43820/ktzjj/
招生方向:
专家类别:
高级
职务:
社会任职:

学术组织任职:

中国毒理学会计算毒理专业委员会委员

中国环境科学学会环境化学专业委员会委员

中国预防医学会卫生毒理专业委员会委员

学术期刊任职:

Environmental Health Perspectives,副主编

Toxicological Sciences,编委

《环境化学》杂志,编委

《环境与职业医学》杂志,编委

承担科研项目情况:

1. 国家重点研发计划合成生物学重点专项,2018YFA0901100,高灵敏环境持久性有毒污染物感知与识别生物系统,2019.7-2024.6,项目负责人。

2. 国家自然科学基金重点项目,21836004,二恶英类污染物系统性神经毒理过程与机制研究,2019/01-2023/12,在研,主持。

3. 国家基金委国家重大科研仪器研制项目,21527901,高通量多功能成组毒理学分析系统,2016/01-2020/12,在研,参与。

4. 国家自然科学基金委杰青,化学环境污染与健康,2016/01-2020/12,400万元,在研,课题负责人。

5. 中国科学院战略性先导科技专项(B类),XDB14030401,典型污染物的环境暴露与健康危害机制,2014/01-2018/12,在研,项目三负责人。

6. 国家自然科学基金委面上项目,21277168,二恶英免疫毒理效应分子作用靶点及机理研究,2013/01-2016/12,已结题,主持。

7. 国家环境保护公益性科研专项项目,201309029,超高灵敏二恶英类生物检测方法的开发与应用,2013/01-2015/12,已结题,主持。

8. 国家自然科学基金委面上项目,21177150,二恶英类污染物神经毒理作用新机制的研究,2012/01-2015/12,已结题,主持。

9. 中国科学院知识创新工程重要方向项目,KZCX2-EW-411,二恶英类污染物免疫毒性的分子机理研究,2011/01-2013/12,已结题,主持。

10. 国家重点基础研究计划项目(973)课题,2010CB933502,纳米材料与技术在水中污染物选择性消除中的应用基础研究,2010/01-2014/12,已结题,主持。

11. 国家自然科学基金委创新群体项目,20921063,持久性有毒化学污染物形态,环境过程与毒理效应,2010/1-2012/12,已结题,群体成员。

获奖及荣誉:

国家杰出青年科学基金(2015年)

中国科学院“百人计划”终期评估优秀奖(2014年)

中国科学院“杰出科技成就奖”(2013年)

持久性有毒污染物国际研讨会“青年科学家奖”(2013年)

中国毒理学学会“国家杰出青年毒理学家奖”(2011年)

中国科学院“百人计划”(2009年)

代表论著:

Hualing Fu, Li Wang, Jiajia Wang, Bennett Brian D, Jianliang Li, Bin Zhao, Guang Hu. Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells. Science of the Total Environment, 2019, 651, 1038-1046.

Wuqun Tao, Jijing Tian, Tuan Xu, Li Xu, Heidi Qunhui Xie, Zhiguang Zhou, Zhiling Guo, Hualing Fu, Xuejiao Yin, Yangsheng Chen, Haiming Xu, Songyan Zhang, Wanglong Zhang, Chao Ma, Feng Ji, Jun Yang, Bin Zhao. Metabolic profiling study on potential toxicity in male mice treated with Dechlorane 602 using UHPLC-ESI-IT-TOF-MS. Environmental Pollution, 2019, 246, 141-147.

Wanglong Zhang, Heidi Qunhui Xie, Yunping Li, Tao Jin, Jiao Li, Li Xu, Zhiguang Zhou, Songyan Zhang, Dan Ma, Mark E. Hahn, Bin Zhao. Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure. Science of the Total Environment, 2019, 669, 621-630.

Yunping Li, Heidi Qunhui Xie, Wanglong Zhang, Yunbo Wei, Rui Sha, Li Xu, Jianqing Zhang, Yousheng Jiang, Tai L. Guo, Bin Zhao. Type 3 innate lymphoid cells are altered in colons of C57BL/6 mice with dioxin exposure. Science of the Total Environment, 2019, 662, 639-645.

Songyan Zhang,Shuaizhang Li, Zhiguang Zhou, Hualing Fu, Li Xu, Heidi Qunhui Xie, Bin Zhao. Development and application of a novel bioassay system for dioxin determination and aryl hydrocarbon receptor activation evaluation in ambient-air samples. Environmental Science & Technology, 2018, 52, 2926-2933.

Hualing Fu, Yingjie Xia, Yangsheng Chen, Tuan Xu, Li Xu, Zhiling Guo, Haiming Xu, Qunhui Xie, Bin Zhao. Acetylcholinesterase is a potential biomarker for a broad spectrum of organic environmental pollutants. Environmental Science & Technology, 2018, 52, 8065-8074.

Bing Yan, Sijin Liu, Bin Zhao, Xiangdong Li, Qiang Fu, Guibin Jiang. China’s fight for clean air and human health. Environmental Science & Technology, 2018, 52, 8063-8064.

Zhiling Guo, Qunhui Xie, Peng Zhang, Yali Luo, Tuan Xu, Yiyun Liu, Hualing Fu, Li Xu, Valsami-Jones Eugenia, Boksa Patricia, Bin Zhao. Dioxins as potential risk factors for autism spectrum disorder. Environment International, 2018, 121, 905-915.

Qunhui Xie, Yingjie Xia, Tuan Xu, Yangsheng Chen, Hualing Fu, Yunping Li, Yali Luo, Li Xu, Karl W K Tsim, Bin Zhao. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells. Environmental Pollution, 2018, 235, 965-973.

Wenjing Tian, Hualing Fu, Tuan Xu, Li Xu, Zhiling Guo, Jijing Tian, Wuqun Tao, Qunhui Xie Bin Zhao. SLC6A19 is a novel putative gene, induced by dioxins via AhR in human hepatoma HepG2 cells. Environmental Pollution, 2018, 237, 508-514.

Tuan Xu, Qunhui Xie, Yunping Li, Yingjie Xia, Yangsheng Chen, Li Xu, Lingyun Wang, Bin Zhao. CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells. Scientific Reports, 2017, 7, 10103.

Yuying Liu, Xiaoyu Liang, Xiaonan Yin, Jiadi Lv, Ke Tang, Jingwei Ma, Tiantian Ji, Huafeng Zhang, Wenqian Dong, Xun Jin, Degao Chen, Yanchun Li, Songyan Zhang, Heidi Qunhui Xie, Bin Zhao, Tong Zhao, Jinzhi Lu, ZhuoWei Hu, Xuetao Cao, F. Xiao-Feng Qin, Bo Huang. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nature Communications, 2017, 8, 15207.

Zhiling Guo, Changjian Xie, Peng Zhang, Junzhe Zhang, Guohua Wang, Xiao He, Yuhui Ma, Bin Zhao, Zhiyong Zhang. Toxicity and transformation of graphene oxide and reduced graphene oxide in bacteria biofilm. Science of the Total Environment, 2017, 580, 1300-1308 .

Yin Liu, Gaoxing Su, Fei Wang, Jianbo Jia, Shuhuan Li, Linlin Zhao, Yali Shi, YaqiCai, Hao Zhu, Bin Zhao, Guibin Jiang, Hongyu Zhou, Bing Yan. Elucidation of the molecular determinants for optimal perfluorooctanesulfonate adsorption using a combinatorial nanoparticle library approach. Environmental Science & Technology, 2017, 51, 7120-7127.

Li Xu, Bin Zhao. Global environmental health: an interview with Sally Perreault Darney. National Science Review, 2016, 3, 459-462.

Zhiling Guo, Qin Hu, Jijing Tian, Li Yan, Chuanyong Jing, Heidi Qunhui Xie, Wenjun Bao, Robert Rice, Bin Zhao, Guibin Jiang. Proteomic profiling reveals candidate markers for arsenic-induced skin keratosis. Environmental Pollution, 2016, 218, 34-38.

Li Xu, Yangsheng Chen, Heidi Xie, Tuan Xu, Hualing Fu, Songyan Zhang, Karl Tsim, Cathy Bi, Bin Zhao. 2,3,7,8-tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF induced differentiated PC12 cells. Chemico-Biological Interactions, 2016, 259, 282-285.

Qunhui Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L. Xu, Lingyun Wang, Karl W. K. Tsim, Bin Zhao. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-Biological Interactions, 2016, 259, 286-290.

Yu Feng, Jijing Tian, Heidi Qunhui Xie, Jianwen She, Sherry Li Xu, Tuan Xu, Wenjing Tian, Hualing Fu, Shuaizhang Li, Wuqun Tao, Lingyun Wang, Yangsheng Chen, Songyan Zhang, Wanglong Zhang, Tai L. Guo, Bin Zhao. Acute exposure to chlorinated flame retardant Dechlorane 602 suppressed Th1 and enhanced Th2 immune responses in mice. Environmental Health Perspectives, 2016, 124, 1406-1413.

Xichun Li, Ruy Zhang, Bin Zhao, Christoph Lossin, Zhengyu Cao. Cardiotoxicity screening: a review of rapid throughput in vitro approaches. Archives of Toxicology, 2016, 90, 1803-1816.

Yi Zhang, Yabin Wang, Aijuan Liu, Sherry Li Xu, Bin Zhao, Yi Zhang, Hanfa Zou, Wenyi Wang, Hao Zhu, Bing Yan. Modulation of carbon nanotube's perturbation to the metabolic activity of CYP3A4 in the liver. Advanced Functional Materials, 2016, 26, 841-850.

Jijing Tian, Yu Feng, Hualing Fu, Heidi QunhuiXie, Joy Xiaosong Jiang, Bin Zhao. The aryl hydrocarbon receptor: a key bridging molecule of external and internal chemical signals and physiological functions. Environmental Science and Technology, 2015, 49, 9518-9531.

Jing Ma, Xi Chen, Yanan Liu, Qunhui Xie, Yawen Sun, Jingshan Chen, Ling Leng, Huan Yan, Bin Zhao, NaijunTang. Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs. Toxicology and Applied Pharmacology, 2015, 289, 193-202.

Wuqun Tao, Zhiguang Zhou, Li Shen, Bin Zhao. Determination of dechlorane compounds in soil and fish at Guiyu, an electronic waste recycling site in South China. Environmental Pollution, 2015, 206, 361-368.

Chengfang Pang, Andrea Brunelli, Conghui Zhu, Danail Hristozov, Ying Liu, Elena Semenzin, Wenwen Wang, Wuqun Tao, Jingnan Liang, Antonio Marcomini, Chunying Chen, Bin Zhao. Demonstrating approaches to chemically modify the surface of Ag nanoparticles in order to influence their cytotoxicity and biodistribution after single dose acute intravenous administration. Nanotoxicology, 2015, 1-11.

Haiming Xu, Heidi Xie, Wuqun Tao, Zhiguang Zhou, Shuaizhang Li, Bin Zhao. Dioxin and dioxin like compounds suppress acetylcholinesterase activity via transcriptional down-regulations in vitro. Journal of Molecular Neuroscience, 2014, 53, 417-423.

Qin Hu, Robert H. Rice, Qin Qin, Brett S. Phinney, Richard A. Eigenheer, Wenjun Bao, Bin Zhao. Proteomic analysis of human keratinocyte response to 2,3,7,8-tetrachlorodibenzo-p-Dioxin (TCDD) exposure. Journal of Proteome Research, 2013, 12, 5340-5347.

Bin Zhao. Perspectives of the development strategies for a future toxicity testing system in China: challenges and opportunities. Environmental Health Perspectives, 2013, 121, 264-265.

Heidi Qunhui Xie, Haiming Xu, Hualing Fu, Qin Hu, Wenjing Tian, Xinhui Pei, Bin Zhao. AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro. Environmental Health Perspectives, 2013, 121, 613-618.

Wenjing Tian, Heidi Qunhui Xie, Hualing Fu, Xinhui Pei, Bin Zhao. Immuno-analysis methods for the detection of dioxins and related chemicals. Sensors, 2012, 12, 16710-16731.

Chang Wang, Thanh Wang, Wei Liu, Ting Ruan, Qunfang Zhou,Jiyan Liu, Aiqian Zhang, Bin Zhao, Guibin Jiang. The in vitro estrogenic activities of polyfluorinated iodine alkanes. Environmental Health Perspectives, 2012, 120, 119-125.

Michael Denison, Anatoly Soshilov, Guochun He, Danica DeGroot, Bin Zhao. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicological Sciences, 2011, 124, 1-12.

Bin Zhao, Minghui Zheng, Guibin Jiang. Dioxin emissions and human exposure in China: a brief history of policy and research. Environmental Health Perspectives, 2011, 119, A112-113.

Bin Zhao, Danica Degroot, Ai Hayashi, Guochun He, Michael Denison. CH223191 is a ligand-selective antagonist of the Ah (dioxin) receptor. Toxicological Sciences, 2010, 117, 393-403.


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