应用离体生物测试开展污染物的毒理研究

1. 国家自然科学基金项目（青年基金）：腐殖酸和胶体对疏水有机污染物两相分配和生物吸收影响（20207011，2003.1-2005.12）

2. 国家自然科学基金项目：饮用水生产过程中微量有机污染物及其毒性变化规律（50378089，2004.1-2006.12）

3. 北京市自然科学基金项目：北京市不同水体中环境内分泌干扰物分布及生物效应研究（8052018，2005.1-2008.1）

4. 北京市科技计划重大项目课题：自来水水质安全评价指标方法与突发事故的水质保障技术及应用（D0605004040221，2006.1-2007.12）

5. 国家高技术研究发展计划（863探索导向项目）：核受体超家族检测化学品和环境样品内分泌干扰物效应的新技术（2007AA06Z414，2007.8－2010.8）

6. 国家自然科学基金项目：水处理工艺过程中环境内分泌干扰物的变化规律（50778170，2008.1－2010.12）

7. 中国科学院知识创新工程重要方向项目群项目：有毒污染物的分子毒理和筛选技术（ KZCX2-YW-Q02-05，2009－2011）

8. 国家高技术研究发展计划(863计划重大项目)：化学品毒性高通量生物测试与评价技术（2012AA06A302，2012.1-2014.12）

9. 中国科学院前沿科学重点研究项目: 饮用水复合污染风险因子识别与控制原理(QYZDY-SSW-DQC004),2016.10-2020.12,70万元

10. 北京市科技计划课题(Z171100004417025)： 南水北调水质健康效应评估体系标准化研究及应用（子课题负责），2017.4-2019.3， 93万元

王子健、马 梅、饶凯锋、李 剑、李 娜，基于人核受体超家族监测环境内分泌干扰物的新技术及应用，2013年度环境保护科学技术奖二等奖（ 证书编号：KJ2013-2-06-G01）

1. Yan Ye, Jiang Weiwei, Li Na, Ma Mei*, Wang Donghong, Wang Zijian*, Rao Kaifeng. Assessing genotoxicity of 16 centralized source waters in China by SOS/umu test and micronucleus test and initial identification of the potential genotoxicants by GC/MS method and QSAR Toolbox 3.0. Mutation Research/Genetic Toxicology and Environmental Mutagenesis , 2014, 763, 36–43
2.  Yan Ye, Jiang Weiwei, Li Na, Ma Mei*, Rao Kaifeng and Wang Zijian* Application of the SOS/umu test and highcontent in vitro micronucleus test to determine genotoxicity and cytotoxicity of nine benzothiazoles. Journal of Applied Toxicology, 2014, 34（12），1400-1408
3.  Rong Yang, Na Li, Mei Ma*, Zijian Wang, Combined effects of estrogenic chemicals with the same mode of action using an estrogen receptor binding bioassay, Environmental Toxicology and Pharmacology, 2014, 38（3），1382-1389
4.  RongYang, Na Li, Kaifeng Rao, Mei Ma*, ZijianWang, Combined action of estrogen receptor agonists and antagonists in two-hybridrecombinantyeast in vitro, Ecotoxicology and Environmental Safety , 2015, 111, 228–235
5.  Na Li, Weiwei Jiang, Mei Ma*, Donghong Wang, Zijian Wang，Chlorination by-products of bisphenol A enhanced retinoid X receptordisrupting effects, Journal of Hazardous Materials, 2016, 320, 289-295
6.  Ying nan Han, Na Li, YoshimitsuOda, Mei Ma*, Kaifeng Rao, ZijianWang, Wei Jin, Gang Hong, Zhiguo Li, Yi Luo，Evaluation of genotoxic effects of surface waters using a battery of Bioassays indicating different mode of action，Ecotoxicology and Environmental Safety, 2016, 133, 448–456
7.  ZH Huang; N Li; KF Rao; CT Liu; Y Huang; M Ma*; ZJ Wang*, Development of a data-processing method based on Bayesian k-means clustering to discriminate aneugens and clastogens in a high-content micronucleus assay, Human and Experimental Toxicology, 2017.3.15 , 37(3)：285~294
8.  Huang, Chao, Li, Na, Yuan, Shengwu, Ji, Xiaoya, Ma, Mei*, Rao, Kaifeng, Wang, Zijian, 2017. Aryl- and alkyl-phosphorus-containing flame retardants induced mitochondrial impairment and cell death in Chinese hamster ovary (CHO-k1) cells. Environmental Pollution, 230: 775-786.
9.  Han Yingnan, Ma Mei*, Li Na, Hou Rui, Huang Chao, Oda Yoshimitsu, Wang Zijian, 2018. Chlorination, chloramination and ozonation of carbamazepine enhance cytotoxicity and genotoxicity: Multi-endpoint evaluation and identification of its genotoxic transformation products. Journal of Hazardous Materials, 342(Supplement C): 679-688.
Huang C, Xu X, Wang D*, Ma M*, Rao K, Wang Z. The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) [J]. Chemosphere, 2018, 211: 640-647.
10. Yuan S, Huang C, Ji X, Ma M*, Rao K, Wang Z. Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression[J]. Ecotoxicology and Environmental Safety, 2018, 160: 1-9.
11. Huang Z , Li N , Rao K , Liu C , Wang Z *, Ma M*, In vitro Cytotoxicity and Genotoxicity Analysis of Ten Tannery Chemicals Using SOS/umu Tests and High-content In vitro Micronucleus Tests, Combinatorial Chemistry & High Throughput Screening, 2018, 21(4):262-270