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  Deputy Director, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
Highest Education  
  18 Shuangqing Road, Haidian District, Beijing, China
Zip Code  

Education and Appointments:

Dr. Sijin Liu is currently a professor at the Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences (CAS). He received Ph.D from the Institute of Developmental Biology and Genetics, CAS, in 2004. Thereafter, he received the postdoc training in hematology and oncology at MIT and Harvard Medical School from 2004 to 2008. Afterwards, he became an instructor at Tufts Medical School from in 2008. Dr. Liu moved to the current position at the end of 2009. Dr. Liu is a recipient of the NSFC “Outstanding Yong Scientist” award, and is also the chief scientist of “National Basic Research Program of China (973 Program)”.
Research interests: (1) the mechanisms responsible for environmental pollutant-mediated oncogenic effects; (2) nanotoxicity.

Research Interest:

Environmental contaminants and human health

Public Services:

Member of the YFCGD


2015 Science & Technology Award for Young and Middle-aged Talents
2017 Science & Technology Nova Program

Selected Publications:

1.Zhang, J., Wang, S., Gao, M., Li, R., Liu, S.* (2018) Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses. ACS Sustainable Chemistry & Engineering. 6(8):10374-10384.
2.Wu, Y., Wang, F., Wang, S., Ma, J., Xu, M., Gao, M., Liu, R, Chen, W.,* Liu, S.* (2018) Reduction of Graphene Oxide Alters Its Cyto-Compatibility towards Primary and Immortalized Macrophages. Nanoscale. 10:14637-14650.
3.Bai, X., Xu, M., Liu, S.,* Hu, G.* (2018) Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant. ACS Applied Materials & Interfaces. 10(24):20368-20376.
4.Ma, J., Guo, A., Wang, S., Man, S., Zhang, Y., Liu, S., Liu, Y.* (2018) From the Lung to the Knee Joint: Toxicity Evaluation of Carbon Black Nanoparticles on Macrophages and Chondrocytes. Journal of Hazardous Materials. 353:329-339.
5.Qi, Y., Liu, Y., Xia, T., Xu, A., Liu, S.,* Chen, W.* (2018) Biotransformation of Graphene Oxide in Lung Fluids Significantly Alters Its Inherent Properties and Bioactivities towards Immune Cells. NPG Asia Materials. 10:385-396.
6.Gao, M., Li, C., Xu, M., Liu, Y., Cong, M., Liu, S.* (2018) LncRNA MT1DP Aggravates Cadmium-induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with MiR-365. Advanced Science. 5:1800087.
7.Zhu, J., Xu, M., Wang, F., Gao, M., Zhang, Z., Xu, Y., Chen, W.,* Liu, S.* (2018) Low-dose Exposure of Graphene Oxide Significantly Increase Metal Toxicity to Macrophages by Altering Their Cellular Priming State. Nano Research. 11:4111-4122.
8.Yang, Y., Wu, Y., Ren, Q., Zhang, L., Liu, S.,* Zuo, Y*. (2018) Biophysical Assessment of Pulmonary Surfactant Predicts the Lung Toxicity of Nanomaterials. Small Methods. 2(4):1700367.
9.Gao, M., Chen, M., Li, C., Xu, M., Liu, Y., Cong, M., Snag, N., Liu, S.* (2018) Long Non-coding RNA MT1DP Shunts the Cellular Defense to Cytotoxicity through Crosstalk with MT1H and RhoC in Cadmium Stress. Cell Discovery. 4(1):5.
10.Wu, Y., Guo, Y., Song, H., Liu, W., Yang, Y., Liu, Y., Sang, N., Zuo, Y., Liu, S.* (2018) Oxygen Content Determines the Bio-reactivity and Toxicity Profiles of Carbon Black Particles. Ecotoxicology and Environmental Safety. 150:207-214.
11.Gao, J., Li, R., Wang, F., Liu, X., Zhang, J., Hu, L., Shi, J., He, B., Zhou, Q., Song, M., Zhang, B., Qu, G.,* Liu, S., Jiang, G. (2017) Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage. Environmental Science & Technology. 51(23):13938-13948.
12.Zhu, J., Xu, M.,* Gao, M., Zhang, Z., Xu, Y., Xia, T., Liu, S.* (2017) Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents. ACS Nano. 11(3):2637-2651.
13.Liu, J., Wang, L., Du, Y.,* Liu, S*. (2017) An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them Against Oxidative Stress. Advanced Science. 4(10):1700089.
14.Gao, M., Zhao, B., Chen, M., Liu, Y., Xu, M., Wang, Z., Liu, S.,* Zhang, C.,* (2017) Nrf-2-driven Long Noncoding RNA ODRUL Contributes to Modulating Silver Nanoparticle-Induced Effects on Erythroid Cells. Biomaterials. 130:14-27.
15.Wang, Z., Liu, H.,* Liu, S.,* (2017) Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer. Advanced Science. 4(2):1600248.
16.Ma, J., Li, R., Liu, Y., Qu, G., Liu, J., Guo, W., Song, H., Li, X., Liu, Y., Xia, T., Yan, B., Liu, S.* (2017) Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal-of-Entry. Small. 13(15):1603830.
17.Chen, Y., Wu, Y., Sun, B., Liu, S.,* Liu, H.* (2017) Two-Dimensional Nanomaterials for Cancer Nanotheranostics. Small. 13(10):1603446.
18.Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.,* Xu, Y., Liu, S.* (2017) Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment. Advanced Materials. 29(6):1604580.
19.Qu, G., Liu, A., Hu, L., Liu, S.,* Shi, J.* Jiang, G. (2016) Recent Advances in the Analysis of TBBPA/TBBPS, TBBPA/TBBPS Derivatives and Their Transformation Products. Trac Trends in Analytical Chemistry. 83:14-24.
20.Xia, T.,* Zhu, Y., Mu, L., Zhang, Z., Liu, S.* (2016) Pulmonary Diseases Induced by Ambient Ultrafine and Engineered Nanoparticles in Twenty-First Century. National Science Review. 3(4):416-429.
21.Ma, J., Li, R., Qu, G., Liu, H., Yan, B., Xia, T., Liu, Y., Liu, S.* (2016) Carbon Nanotubes Stimulate Synovial Inflammation by Inducing Systemic Pro-Inflammatory Cytokines. Nanoscale. 8(42):18070-18086.
22.Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.* Tian, J., Zhang, T.,* Liu, H.* (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Advanced Materials. 28(38):8379-8387.
23.Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.,* Zhang, Z.,* Chen, W., Liu, S.* (2016) Improved in Vitro and in Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10(3):3267-3281.
24.Gao, M., Liu, Y., Chen, Y., Yin, C., Chen, J., Liu, S.* (2016) miR-214 Protects Erythroid Cells Against Oxidative Stress by Targeting ATF4 and EZH2. Free Radical Biology & Medicine. 92:39-49.
25.Ma, J., Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, R., Zuo, Y., Xia, T.,* Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9(10):10498-10515.
26.Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.,* Liu, S.* (2015) Silver Nanoparticle-Induced Hemoglobin Decrease Involves Alteration of Histone 3 Methylation Status. Biomaterials. 70:12-22.
27.Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid Zinc Finger 1 (MZF-1) Suppresses Prostate Tumor Growth through Enforcing Ferroportin-Conducted Iron Egress. Oncogene. 34(29):3839-3847.
28.Wang, Z., Xia, T.,* Liu, S.* (2015) Mechanisms of Nanosilver-Induced Toxicological Effects: More Attention Should be Oaid to Its Sublethal Effects. Nanoscale. 7(17):7470-7481.
29.Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y.,* Liu, S.* (2014) Nanosilver Incurs an Adaptive Shunt of Energy Metabolism Mode to Glycolysis in Tumor and Nontumor Cells. ACS Nano. 8(6):5813-5825.
30.Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a Crucial Role in Gegulating Prostate Tumor Growth through Interaction with c-Myc. Oncogene. 33(49):5582-5591.
31.Qu, G., Liu, S.,* Zhang, S., Wang, L., Wang, X., Sun, B., Yin, N., Gao, X., Xia, T., Chen, J., Jiang, G. (2013) Graphene Oxide Induces Toll-Like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7(7):5732-5745.
32.Wang, Z., Liu, S.,* Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013) Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7(5):4171-4186.
33.Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, Jiang, G. (2012) Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4(7):2239-2244.
34.Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., Chen, J.J.* (2012) Heme-Regulated eIF2alpha Kinase Activated Atf4 Signaling Pathway in Oxidative Stress and Erythropoiesis. Blood. 119(22):5276-5284.
35.Liu, S., Goldstein, R.H., Scepansky, E.M., Rosenblatt, M.* (2009) Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Research. 69:(22)8742-8751.
36.Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., Chen, J.J.* (2007) The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. Journal of Clinical Investigation. 117(11):3296-3305.

Supported Projects:

(1) Project?supported?by?the?Key?Program?of?the?National?Natural?Science?Foundation?of?China (Grant No. 21637004, 2017.01-2021.12).
(2) Project?supported?by?the?Young?Scientists?Fund?of?the?National?Natural?Science Foundation?of?China (Grant No. 21425731, 2015.01-2019.12).
(3) Project supported by the National Basic Research Program of China (973 Program) (Grant No. 2014CB932000, 2014.01-2018.12).

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Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, People’s Republic of China