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Location:Home > People > Professor

Professor
Details
Name  
WANG Hailin
Title  
  Leader of DNA damage and molecular toxicology group
Highest Education  
  Ph.D
Office  
  18 Shuangqing Road, Haidian District, Beijing, China
Phone  
  0086-10-62849600
Zip Code  
  100085
Fax  
  0086-10-62849600
Email  
  HLWang@rcees.ac.cn

Education and Appointments:

Dr. Hailin Wang obtained his Ph D at the Dalian Institute of Chemical Physics, Chinese Academy of Science, in 1997, and had done research as a postdoctoral fellow and research associate (2000-2005) at the University of Alberta, Canada. He has his expertise in epigenetics, in particular, DNA methylation and demethylation, a pioneer for the discovery of DNA N6-methyladenine in high eukaryotes. He developed advanced analytical technologies (UHPLC-MS/MS, qPCR, genome-wide sequencing) for characterization and functional study of DNA 5-methylcytosine and its oxidation intermediates. He for the first time showed the enhancement of genome-wide 5-hydroxymethylcytosine by nutrient vitamin C, revealing a role of vitamin C in the regulation of DNA modification, and his study established a direct linkage among vitamin C, Tet dioxygenases, and DNA methylation. He further extended these technologies for study of other DNA modifications, and as a world-wide seminal work, he discovered new DNA modification (N6-methyladenine) in high eukaryotes (Cell, 2015). He also has his expertise in ultrasensitive analytical technologies (e.g., capillary electrophoresis-laser induced fluorescence polarization, single molecule fluorescence imaging, and UHPLC-MS/MS) for detection of carcinogenic DNA adducts and for study of DNA-repair proteins interactions. He published 100 peer-reviewed papers on leading journals, including Cell, Cell Stem Cell, Mol Cell, Proc. Natl. Acad. Sci. USA, J. Am. Chem. Soc., Cell Res. Cell Discovery, Nucleic Acids Research, Analytical Chemistry. He won a number of wards, “Presidential Special Award for Graduate Student” by the Chinese Academy of Sciences (1997), “CAIA” Scientific Award, first medal (2010, 2013), “Excellent Nominee” for “Hundreds of Talents” plan by the Chinese Academy of Sciences (2011), “CAIA” Scientific Award, Special medal (2015), Outstanding Science and Technology Achievement Prize of the Chinese Academy of Sciences (2013), “Distinguished Young Scientists” by the National Science Foundation of China (2011), Excellent for “Distinguished Young Scientists” by the National Science Foundation of China (2016).


Research Interest:

Ultrasensitive bioanalytical technology and its applications for study of genetics and epigenetics-based toxicology

Public Services:

Editorial Advisory Member,
DNA repair (2018-)
Analytical Chemistry (2018-2020)
Chinese Journal of Environment Chemistry (2010- )
Acta Chimica Acta (2012-)
Journal of Separation Science (2014-)
Genomics Proteomics Bioninformatics (2015-)
Journal of Environmental Science (2017-)

Associate Editor
Encyclopedia of Analytical Chemistry (2012-)


Honors:

“National Awardee for Hundred, Thousand and Ten Thousand Talent Engineering Project” (“百千万人才工程国家级人选”)
Ministry of Human Resources and Social Security of P. R. China, joined with other six ministries of P.R. China, including Ministry of Science and Technology, Ministry of Education, 2017

“Distinguished Young Scientist”, Excellent Award
Natural Science Foundation of China, 2011-2015

100 Talent Scientists Program, Excellent Award
Chinese Academy of Sciences, Beijing, China, 2005-2009

CAIA Awards Special Medal, 2015
Chinese Association of Instrumental Analysis, Beijing, China

CAIA Awards First Medal, 2010, 2013
Chinese Association of Instrumental Analysis, Beijing, China

CAIA Awards Second medal, 1995, 1998, and 1999
Chinese Association of Instrumental Analysis, Beijing, China

Presidential Special Graduate Award, 1997
Chinese Academy of Sciences, Beijing, China

 

Selected Publications:

BOOK and BOOK CHAPTERS:
Wang, H.*; Lu, M.; Dever, B; Shen, S.; Le, X. C. Section 3.15: Affinity capillary electrophoresis in the study of DNA damage, repair, and methylation. Book: Comprehensive sampling and sample preparation. Elsevier Press. 2012)
Lu, M.*; Wang, H.; Geisel, Z.; Le, X. C. Section 3.26: Enzyme digestion for arsenic speciation. Book: Comprehensive sampling and sample preparation. Elsevier Press. 2012
Jiang, G. B.; Wang, H.; Dai J. Y.; Lv, X. F.; Shao, J. A Textbook of morden toxicology Text (3rd edition, edited by Enerst Hodgson). Translation book (English to Chinese). Science Press (china). 2011

1.Liu, J.#; Jiang, J.#; Mo, J.#; Liu, D.#; Cao, D.; Wang, H(ailin)*; He, Yufei*; Wang H(ongyang).* Global DNA 5-hydroxymethylcysotine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, doi: 10.1002/hep.30146. (IF = 14.079)
2.Yang, X.#; Yang, Y.#; Sun, B. F.#; Chen, Y. S.#; Xu, J. W.#; Lai, W. Y.#; Li, A.; Wang, X.; Bhattarai, D. P.; Xiao, W.; Sun, H. Y.; Zhu, Q.; Ma, H. L.; Adhikari, S.; Sun, M.; Hao, Y. J.; Zhang, B.; Huang, C. M.; Huang, N.; Jiang, G. B.; Zhao, Y. L.; Wang, H. L.*; Sun, Y. P.*; Yang, Y. G.* 5-methylcytosine promotes mRNA export – NSUN2 as the methyltransferases and ALYREF as an m5C reader. Cell Res. 27:606-625 (2017) (Cover, highlighted). (IF = 15.606)
3.Zhao, B.#; Zhang, D#.; Li, C.; Yuan, Z.; Zhong, S.; Jiang, G.; Yang, Y. G.; Le, X. C.; Weinfeld, M.; Zhu P.; Wang, H.* ATpase activity tightly regulates RecA nucleofilaments to promote homologous recombination. Cell Discov. 3:16053 (2017).
4.Zhang, G.#; Huang, H.#; Liu, D.#;, Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li,C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.*; Chen, D.* N6-methyladenine DNA modification in Drosophila. Cell, 161:893-906 (2015). (Previewed by Cell, Cover, IF = 31.398) (Google citation: 202)
5.Zhao, C.; Wang, H.*; Zhao, B. L.; Li, C. P.; Yin, R.; Song, M.; Liu, Z.; Jiang, G. B. Boronic acid-mediated polymerase chain reaction for gene- and fragment-specific detection of 5-hydroxymethylcytosine. Nucleic Acids Res., 42: e81 (2014). (IF = 11.561)
6.Zhao, B. L.#; Yang, Y. #; Wang, X.#; Chong Z.; Yin, R.; Song, S. H.; Zhao, C.; Li, C.; Huang, H.; Sun, B. F. Wu, D.; Jin, K. X. Song, M.; Zhu, B. Z.; Jiang, G.; Danielsen, J. M. R.; Xu, G. L.; Yang, Y. G.*; Wang, H.* Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res., 42:1593-1605 (2014). (IF = 11.561)
7.Yin, R.; Mao, S.-Q.; Zhao, B.; Chong, Z.; Yang, Y.; Zhao, C.; Zhang, D.; Huang, H.; Gao, J.; Li, Z,; Jiao, Y.; Li, C.; Liu, S.; Wu, D.; Gu, W.; Yang, Y. G.; Xu, G. L.; Wang, H.* Ascorbic Acid Enhances Tet-mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals. J. Am. Chem. Soc., 135:10396-10403 (2013). (Highlighted by Nature Reviews Genetics) (IF = 14.357) Google citation: 240)
8.Liu, S.; Zhao, B.; Zhang, D.; Li, C.; Wang, H*. Imaging of Non-uniform Motion of Single DNA Molecules Reveals the Kinetics of Varying-Field Isotachophoresis. J. Am. Chem. Soc., 135:4644-4647 (2013). (IF = 14.357)
9.Zhang, D. P.; Lu, M.; Wang, H.* Fluorescence anisotropy analysis for mapping aptamer-protein interaction at the single nucleotide level. J. Am. Chem. Soc., 133: 9188-9191 (2011). (IF = 14.357)
10.Wang, H.; Lu, M.; Tang, M.-S.; Van Houten, B.; Ross, J. B. A.; Weinfeld, M.*; Le, X. C*. DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway. Proc. Natl. Acad. Sci. USA, 106: 12849-12854 (2009).

 


Supported Projects:
The grants supported by the Ministry of Science and Technology of China (2016YFC0900300), the National Natural Science Foundation of China (9174321, 21327006, 21435008, and 21621064), and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB14030200), the Key Research Program of Frontier Sciences, CAS (QYZDJ-SSW-DQC017), and the K. C. Wong Education Foundation.
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Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, People’s Republic of China